Sarcouncil Journal of Medical Sciences

Abstract: This paper gathered 80 patients who were selected in a number of various hospitals in Iraq and had the intention of investigating the exact processes, which contribute to the formation and development of rheumatologic diseases, both on a cellular and molecular scale. Rheumatic illnesses are the most common chronic disease in humans and the most common cause of lifelong disability, complex diseases that are more best comprehended when enabled to apply molecular genetic analysis in rheumatology. They identify potential infectious factors, and the genetic factors influencing the determinants of the disease on an individual level. The knowledge of causation of illnesses, severity analysis, choice of therapy and classifications of data associated with a patient are enhanced by researching into the heterogeneity of genes. Clinical and pathological features of rheumatic diseases have heterogeneity predisposed to progression. This multifactorial aspect of the diseases determines the heterogeneity of the nature of rheumatic diseases because in some instances, the multifactorial nature of the environment and the polygenic background not only predisposes to the disease but also determines the severity and the outcome of the disease. Knowledge of the molecular genetic complexity and complexity of these disorders also remains unfinished and there is still no criteria to form subgroups that ought to be treated differently in patients. We have arrived at this research conclusion that as a result of genetic analysis approaches made it possible to demonstrate that the microbial factor and the genetic peculiarities of the person matters in the development of rheumatic diseases